Dr. Dick Smith’s research involves the development and application of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry and their applications in biological and biomedical research. Much of his research over the last 15 years has focused on developing and applying new ultra-sensitive and comprehensive methods for quantitatively probing the entire array of proteins expressed by a cell, tissue or organism, i.e., their “proteomes.” Current interests also include greatly increasing the throughput and sensitivity of proteomics and metabolomics measurements to meet systems biology research needs. In addition to being a Battelle Fellow and Chief Scientist at PNNL, Dr. Smith is an adjunct faculty member of the Department of Chemistry at both Washington State University and the University of Utah, and an affiliate faculty member of the Department of Chemistry, University of Idaho. He is also Director of the NIH Research Resource for Integrative Proteomics located at PNNL. Dr. Smith has presented more than 350 invited and plenary lectures at national and international scientific meetings, is the author/co-author of more than 650 publications, holds 30 patents, and has received seven R&D 100 Awards.