Dr. Amanda Paulovich, a medical oncologist, directs the Early Detection Initiative at Fred Hutchinson Cancer Research Center. She earned M.D. and Ph.D degrees at the University of Washington. While a graduate student in genetics, she trained in the laboratory of Nobel laureate Dr. Lee Hartwell where she studied checkpoint regulation of cell cycle progression in yeast in response to DNA damaging agents as well as genetic mechanisms used by yeast cells to tolerate irreparable DNA damage. Subsequently, she did a residency in internal medicine at Massachusetts General Hospital, a fellowship in Medical Oncology at the Dana-Farber Cancer Institute, and postdoctoral training with Dr. Eric Lander at the Broad Institute of Massachusetts Institute of Technology. In September 2004, Dr. Paulovich joined the faculty of the Clinical Research Division at the Fred Hutchinson Cancer Research Center as Director of the Center’s new Early Detection Initiative, and is continuing to pursue her interest in biomarkers of cancer risk and detection, using proteomic technologies such as mass spectrometry. She participates in several large, multi-institutional biomarker discovery initiatives and is a Steering Committee member for the International Cancer Biomarker Consortium (ICBC), a large-scale effort similar to the Human Genome Project aimed at making significant progress in the discovery of biomarkers by facilitating highly coordinated research and leveraging resources and expertise from around the world. She also serves on the advisory Boards of Bio-Rad Laboratories, the Canary Foundation, and the Women’s Bioethics Project.